Prevalent genotypes of methylenetetrahydrofolate reductase (MTHFR) in recurrent miscarriage and recurrent implantation failure
نویسندگان
چکیده
منابع مشابه
Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage
Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage (RM). To investigate this, the sperm DNA fragmentation in partners of 35 women with recurrent implantation failure (RIF) following in vitro fertilization, 16 women diagnosed with RM and seven recent fathers (control) were examined. Sperm were examined pre- and post-densit...
متن کاملGenetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure
The one-carbon metabolism pathway disorder was important role in successful pregnancy. The MTHFR and TS protein were crucial factor in one-carbon metabolism. To investigate the association between recurrent implantation failure (RIF) and enzymes in the one-carbon metabolism pathway. A total of 120 women diagnosed with RIF and 125 control subjects were genotyped for MTHFR 677C>T, 1298A>C, TSER 2...
متن کاملI-24: Recurrent Implantation Failure
Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...
متن کاملmethylenetetrahydrofolate reductase c677t and a1298c polymorphisms in male partners of recurrent miscarriage couples
background: methylenetetrahydrofolate reductase (mthfr) single-nucleotide polymorphisms (snps) c677t and a1298c have been described as strong risk factors for idiopathic recurrent miscarriage (rm). however, very few studies have investigated the association of paternal mthfr snps with rm. the aim of the present study was to evaluate the prevalence of paternal c677t and a1298c snps among iranian...
متن کاملEvaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...
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ژورنال
عنوان ژورنال: Journal of Assisted Reproduction and Genetics
سال: 2018
ISSN: 1058-0468,1573-7330
DOI: 10.1007/s10815-018-1205-6